Endocrine Abstracts

A 43-year-old roman, previously living in France was referred to the endocrinology department for Hashimoto’s hypothyroidism in 2017. Thyroid function was easily normalized by a treatment by thyroxine. She had also a medical history of severe alopecia since the age of 20. The diagnosis of androgenetic alopecia was made at that time by a French dermatologist and treatment by estradiol valerate 2 mg with cyproterone acetate (CPA) 50 mg was started. The dose of CPA was lower...

Section: Case history: 73-year old gentleman referred from GP with a two month history of worsening dizziness, malaise, postural hypotension and general deterioration and spiking pyrexia ranging 38-40°C over 3 weeks. PMH of NSCLC T2b N0- left lower lobectomy & chemotherapy 3 years prior.Section: Investigations and treatment: At re-presentation his CT TAP showed bilateral bulky adrenal glands but no other abnormality. The patient’s bloods sh...

Background and case: A 38-year-old man presented acutely with left-sided retro-orbital pain, a heavy/numb sensation in his left arm and blurred vision and diplopia on left lateral gaze. Baseline biochemistry, liver function and haematology were normal. His TSH was 3.9 (0.3–4 mU/l) and CRP 92 mg/l (<10). Plain CT head was unremarkable as was the MRI as reported, and atypical migraine was suspected. Vertical diplopia on left lateral gaze and left upper arm paraesthesia ...

Oestrogens can prevent or delay the age-related deterioration of the skin. Post-menopausal women have a reduced rate of wound healing, which can be reversed by oestrogen therapy. However, the mechanisms underlying these effects remain poorly understood. To understand more fully the role of oestrogen in the cutaneous wound healing process we have measured migration, proliferation and the secretion of mitogenic factors by cultured dermal fibroblasts in response to17β-oestra...

A 64 year old man presented in 1992 with a dense bitemporal hemianopia and no endocrine symptoms. CT showed a large pituitary adenoma with suprasellar extension. He underwent transphenoidal resection of the tumour. Histology showed a typical chromophobe adenoma with no immunohistochemical staining. His vision recovered.He was followed regularly with serial MRI scan. No change was seen in the size of the residual intrasellar tumour. Pituitary testing show...

The outcome of parathyroid surgery is often not clear for at least 24 hours after an operation. Frozen section is not always helpful in distinguishing between adenoma and hyperplasia. Minimally invasive surgical techniques are being refined so the need for perioperative assurance about the effects of surgery has increased. PTH assays have been adapted to give results in less than 20 minutes. We have tested the value of intraoperative PTH measurements in 10 surgical cases under...

The role of oestrogens on the regulation of human hair growth is poorly understood. Using whole human scalp hair follicle organ culture, we have recently demonstrated, that human hair growth is inhibited by 17beta-oestradiol, but not by the biologically inactive isomer 17alpha-oestradiol. Using immunohistochemistry, we have also demonstrated the presence of both ERalpha and ERbeta in the pilosebaceous unit and the dermal papilla, a mesenchymal structure that controls the diffe...

A 71 year old woman presented with visual loss. MR scanning demonstrated a massive invasive pituitary adenoma. She had no features of endocrine dysfunction. 0900hrs cortisol was 278nmol/L. Haemorrhage limited transphenoidal surgery to biopsies. Postoperative CSF leak was repaired 3months later. Histology revealed a corticotroph adenoma on immunostaining.At endocrine follow-up, afternoon cortisol was 645nmol/L, and 875nmol/L fasting, falling after glucago...

Background: A minority of women with polycystic ovary syndrome (PCOS) is lean, and several individuals have no signs of hyperandrogenaemia. Earlier we showed that lean PCOS patients have no increased visceral adiposity. The aim of the present study was study is to characterize the metabolic and hormonal status a group of lean PCOS cases.Methods: In this cross-sectional study ten Caucasian women with PCOS and ten controls carefully matched for age and BMI...

Background: Glucolipotoxicity contributes to declining B-cell function and acceleration of type 2 diabetes (T2DM). Intensive insulin therapy has been shown to rapidly reverse glucolipotoxicity and improve B-cell function, particularly if given soon after diagnosis. Recent trials in adults have shown promise, with 50% in remission at 1 year after intensive insulin therapy.Methods: We report 4 cases of young people with T2DM treated with intravenous insuli...